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Metabolites and ratios of metabolites were considered an autism-associated biomarker if the average performance had a sensitivity of at least 4.5% (indicating a subpopulation of at least 4.5% of the autism study participants that were biomarker-positive) and the proportion of the biomarker-positive (PMP) population of at least 90% autistic individuals (equivalent to the positive predictive value (PPV) of 90% within the CAMP study population prevalence)
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This process can be disrupted by the intake of calories or substances that provoke an insulin response
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This observation supports the postulation of the fact that oxidative stress may well be one of the driving forces behind the disease progression (61)
By mimicking amylins biological activity, Cagrilintide has been designed to extend and enhance these natural effects, making it a key molecule of interest in metabolic and obesity research
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