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The bundle is widely used in in-vitro experiments investigating receptor signaling and endocrine pathway behavior

10.1155/2019/9084643 44 LojoN.RasicZ.Zenko SeverA.KolencD.VukusicD.DrmicD.et al (2016)

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Participants were divided into those receiving concurrent hormone therapy and those who were not, with groups carefully matched by age, BMI, and clinical history to reduce the most obvious confounding variables