doi: 10.1016/j.cell.2012.03.042 22 Mahoney-SnchezLBouchaouiHAytonSDevosDDuceJADevedjianJ-C
By contrast, the expression of CBS is inducible by dimethyl fumarate (DMF) through nuclear factor erythroid 2-related factor 2 (NRF2) activation and CpG islands DNA hydroxymethylation
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The risk of asthma is higher in children exposed to acetaminophen during pregnancy, and that risk is exacerbated by maternal genetic variants related to acetaminophen detoxification.[ref] Genetic interactions with acetaminophen: With multiple routes of detoxification, most people can take acetaminophen without liver damage
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Additionally, SAL impacts the thermal stability of Keap1, with modifications to the Cys151 residue of Keap1 being crucial for Nrf2-dependent transcriptional activation mediated by SAL
