Early observational data suggests that patients on GLP-1 therapy for weight loss may see B12 levels decline by 10-15% over six to twelve months, depending on baseline status and dietary intake
These medications may reduce how long B12 remains in the body, requiring individuals to supplement more frequently to maintain appropriate levels
Nat Rev Gastroenterol Hepatol
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Under current FDA guidance these peptides also are ineligible for compounding - the process in which pharmacies mix made-to-order medications for patients