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111 For bidirectional transport two receptors may be needed, as in the case of A, which is transported out of the brain by LRP1 and into the brain by RAGE

This risk is based on animal studies in which semaglutide (the active ingredient in Wegovy) caused thyroid cancer

Short-term, high-dose steroid bursts (such as for acute inflammation) create more dramatic appetite surges than maintenance doses

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In rare cases, more severe side effects may occur

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