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In the presence of transferrin insufficiency and iron overload, iron toxicity induces oxidative stress through the Fenton reaction, the most biologically potent ROS reaction, to produce superoxide anions and hydroxyl radicals, resulting in direct damage to follicles, oocytes, sperm, and embryos (121, 122)

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Co-exposure ochratoxin A and triadimefon influenced the hepatic glucolipid metabolism and intestinal micro-environment in mice

This can reduce side effects while maintaining or improving efficacy a principle well-established in pharmacology