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PMID 867037

The significance of differences between the means of the variables in the six study groups was determined using one-way ANOVA followed by Tukey's post-hoc test

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Because preservative effectiveness is only required to be demonstrated for 28 days after first entry, standard multiple-dose vial practice, reflected in CDC injection safety guidance, is to date the vial at first puncture and discard it 28 days later

McCrea G, Miaskowski C, Stotts N, et al

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