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Inclusion and ethics statement All collaborators who fulfilled the authorship criteria defined by Nature Communications have been appropriately included as authors, recognizing their vital contributions to both the studys design and its implementation

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Inflammation-associated anorexia, prevalent gastrointestinal symptoms due to slow intestinal transit, disrupted appetite regulation, and energy expenditurelinked to overexpression of leptin, increased bound leptin, irregular ghrelin secretion, and blunted ghrelin responsescorrelate with liver disease severity and systemic inflammation, further reducing food intake quantity and frequency of spontaneous food consumption (12, 16)

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