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GSDMD-mediated cardiomyocyte pyroptosis promotes myocardial I/R injury

Consequently, VRK2 expression emerges as a dual-function biomarker: its targeted inhibition shows therapeutic efficacy in VRK2-high malignancies, while its deficiency serves as a predictive indicator for metabolic-targeted interventions

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Addressing these issues often requires a tailored approach that includes a combination of lifestyle interventions, nutritional counseling, psychological support, and, when necessary, medical treatment