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FRGS/1/2022/TK05/UPM/01/3

These medications, which function by slowing gastric emptying, can lead to severe, chronic digestive issues, including persistent nausea, vomiting, abdominal distention, and the need for intensive medical interventions like IV therapy or feeding tubes

What doesn't warrant an immediate dose increase is a slow week or a difficult few days

Am J Cardiol 181:8793

Two kidney outcomes were examined: new onset macroalbuminuria and a composite renal outcome (including a combination of development of new-onset macroalbuminuria, decline in estimated glomerular filtration rate (eGFR), progression to end-stage kidney disease, or death attributable to kidney causes, as reported in each study)

In clinical trials submitted for regulatory approval, headaches were reported in participants taking tirzepatide, though less frequently than gastrointestinal symptoms such as nausea, diarrhoea, and vomiting