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SIRT1, an NAD + -dependent class III histone deacetylase, regulates hepatic lipid metabolism through deacetylation of multiple transcription factors and metabolic enzymes, exerting a bidirectional effect on lipid homeostasis by inhibiting fat synthesis and promoting fatty acid oxidation

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STEP-1 Trial (NEJM, 2021): 1,961 adults with BMI 30 (or 27 with a weight-related condition)

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