Oral GLP-1 vs
The goal is to mimic the environment your body evolved in, through things like sunlight, clean food, community, movement, and rest
PA potential solution for this challenge is to explore formulations offering less frequent injections andral formulations, which may provide a more viable long-term treatment solution
Not surprisingly, a subset of DPP-4 inhibitors evaluated during pre-clinical development were found to suppress DPP-8 and/or DPP-9 activity, causing severe toxicities, including weakened T cell activation and proliferation, impaired preadipocyte differentiation (Han et al., 2015), enlarged lymph nodes, splenomegaly, etc
IGF 1 LR3 (Long R3 Insulin-like Growth Factor-I or Long R3IGF-I) is an 83 amino acid analog of human IGF-I actually comprising the complete human IGF 1 LR3 sequence but with the substitution of an Arg for the Glu at position 3, as well as a 13 amino acid extension peptide at the N-terminus
10.1007/BF01986897 4