Most of these involve the stifle (knee) joint, where the cranial cruciate ligament, menisci, and articular cartilage work together and where the majority of canine orthopedic injuries occur: Cranial Cruciate Ligament Disease: The canine equivalent of human ACL tears, extremely common in medium to large breeds
Thevis, M., Kuuranne, T
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Interestingly, biopsies from asthma patients support this observation, with reduced levels of RAMP1 compared to the controls ( Calcitonin-gene related peptide modulates the Th9 response (response related to TIHS), inducing the expression of GATA3 and PU.1 (transcription factor of Th9 cells) and IL-9 production, enhancing airway inflammation (Mikami et al., 2013)
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