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For most healthy users the risk is low and manageable

Improper storage increases contamination risks despite preservative protection

However, the most significant difference is between systemic circulation (minutes) and topical application on the skin (hours of local residence time)

While classical gene mutations are region-limited, epimutations often occur early in cancer development and have a genome-wide impact, boosting on the one hand the expression of cell survival genes or proto-oncogenes and deactivating on the other hand tumor suppressor genes (TSGs), DNA repair mechanisms as well as cell division brakes, thus leading to carcinogenesis (Karius et al., 2012

Justyna Moisio, D.O., brings expertise and a personalized approach to every treatment

The two terms are used interchangeably in clinical and research literature