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The antifibrotic effect of honokiol is achieved by upregulating the activity and expression of SIRT3, deacetylating pyruvate dehydrogenase E1 (PDHE1) at lysine 385, further inhibiting the PDHE1 phosphorylation and restoring pyruvate dehydrogenase complex (PDH) enzyme activity, thus preventing kidney fibrosis in the UUO-induced renal fibrosis mice model (Zhang et al., 2021b)
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