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By the end of an 8-week supplementation with L-Carnitine-combination, total mTOR increased by 81% compared to the baseline without significantly affecting mTOR phosphorylation, as well as its downstream proteins, possibly because of the reported delay in the phosphorylation capacity of this protein kinase in the elderly [38]
A conservative approach using 0.25 mg daily for the first two weeks allows assessment of individual response before considering increases
RR estimates were consistent with these findings with RRs of 1.17 at 1-year and 1.21 at 5-years
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