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What sets tirzepatide apart from semaglutide is its unique dual-action mechanism: it acts as an agonist for both GLP-1 receptors and GIP (glucose-dependent insulinotropic polypeptide) receptors

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Interestingly, a study conducted on Mexican healthy elderly (decreased age-associated endogenous vitamin D synthesis) suggested that despite living in a country with appropriate UV radiation exposure due to lower latitude, vitamin D insufficiency (91.3%) is a ubiquitous matter throughout the year resulting in correlating TNF- serum levels, potentially explaining the increased susceptibility of older adults to systemic inflammation and associated diseases [192]

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