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Porter, K

In our experience, BAP1 -inactivated melanocytomas are encountered less frequently than deep penetrating (beta-catenin activated) melanocytomas, and this likely reflects both the concerning clinical appearance of deep penetrating (beta-catenin activated) melanocytomas prompting biopsy, as well as the fact that beta-catenin activated melanocytomas typically harbor a single additional activating mutation (CTNNB1 mutation) instead of the two additional alterations (mutation of BAP1 followed by loss of the wild-type allele) in BAP1 -inactivated melanocytomas and thus may be more prevalent

it's documented here rather than silently picked for you

Over the long run, the oral version may also be less costly, Dr

Mentioning that you are aware of these developments signals to your doctor that you are genuinely engaged with the science, not just chasing a trend