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This indicates prolongation of the PR interval more than 95 th percentile for age and heart rate and is due to impairment in the AV node conduction caused by increased vagal tone, AV nodal ischemia or drugs such as digoxin and beta-blockers

Beginning at 7 weeks of age, wild-type and Fbn1 C1039G/+ mice are treated with oral losartan (0.6 g/L in drinking water

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