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However, Mirren, who began her acting career playing Cleopatra and Lady Macbeth in Royal Shakespeare Company productions of the 1960s and 1970s, has appeared in more than 30 productions for British, Australian, and American television

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Estrogen, through its widespread receptors in brain areas of relevance to the addiction circuitry, can influence neurotransmission, lead researcher Erika Comasco, PhD, assistant professor in the Department of Womens and Childrens Health,Neuropsychopharmacology at Uppsala University in Sweden, told Healthline