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Continue tirzepatide at 5mg weekly (first escalation)

doi: 10.1159/000109998 115 FratiglioniLLaunerLJAndersenKBretelerMMCopelandJRDartiguesJFet al

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But more evidence is needed for safety and long-term use

Additional emerging data further support the idea that hormonal status influences both weight loss responsiveness and body composition outcomes during GLP-1 therapy [17], consistent with the mechanistic picture of HRT restoring a metabolic environment that makes GLP-1 receptor agonists more effective

Neurogenesis in Depression and Its Relation to GLP-1 In the brain, neurogenesis is a critical repair response against stress and age (Dranovsky et al., 2011)