gallbladder issues with glp-1 GLP-1s are associated — but it’s more nuanced than “the medication caused it.”, A big reason is rapid weight loss (which increases gallstone risk), plus how these meds can Gallbladder Removal After Ozempic: Can

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People with a personal or family history of medullary thyroid carcinoma, multiple endocrine neoplasia type 2, pancreatitis, or severe gastrointestinal conditions should avoid GLP1 weight-loss drugs unless specifically advised by their physician

In patients with Parkinsons disease on levodopa monotherapy, vitamin B supplementation can increase peripheral levodopa metabolism and thus reduce the amount of levodopa reaching the central nervous system, worsening symptom control