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71 On the basis of structural analysis, it is possible that zinc binding to the eIF2 complex promotes the stability of the inactive eIF2BeIF2-P (phosphorylated) complex by stabilizing the structure of eIF2 and insulating phosphorylated eIF2 from phosphatase hydrolysis

10.1016/j.rapm.2004.06.008 45 SunJ.ZhangX.BroderickM.FeinH

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More recently, a randomized, double-blind, placebo-controlled trial in 215 men, aged 35 to 55 years, examined the effects of supplemental B vitamins (at 3 to 13 times the current RDA, except for folic acid which was included at a dose equivalent to the RDA), vitamin C (500 mg/day), and the minerals, zinc (10 mg/day), calcium (100 mg/day), and magnesium (100 mg/day) on mood and perceived stress (134)