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Clinical evidenceparticularly for -lipoic acid, curcumin, green tea, vitamin B12, melatonin, and CoQ10supports symptomatic relief and functional improvement, although trials remain small and heterogeneous

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Inhibition of another intestinal efflux transporter, breast cancer resistance protein (BCRP), has also been tested, but the IC 50 (360 M) may be inconsequential (Wagmann et al., 2018)

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