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A recent large systematic review addressed the concern vigorously (Yasueda 2015)

In addition to supporting their function, zinc is critical for preventing macrophage apoptosis

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Patients should be alert to: Persistent constipation , which may increase diverticular pressure New or worsening abdominal pain , especially if localised to the lower abdomen Changes in stool consistency or frequency Fever or systemic symptoms suggesting infection Communication with healthcare providers is vital