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In rodents, pasireotide, a somatostatin analogue capable of activating SSTRs 1, 2, 3, and 5, is capable of inhibiting CRH-stimulated ACTH release in contrast to octreotide (selective for SSTRs 2 and 5), which was less efficacious (129)

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This means Ozempics weight-loss potential likely falls somewhere between these two trial results, though it remains lower than Mounjaro in equivalent-dose comparisons

Buse M.D., Ph.D.] Liraglutide is a GLP-1 analog which has 97% sequencesimilarity toward GLP-1

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Current UK practice generally does not recommend routine stopping of GLP-1 receptor agonists for all patients before surgery