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Con la implementacin de esta terapia se empezaron a conocer las complicaciones asociadas con hiperglucemia crnica como alteraciones microvasculares (retinopata, neuropata y nefropata), y macrovasculares (angina, infarto, accidente cerebrovasculares)

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Intracellular trafficking of FcRn and its cargo is controlled by Rab GTPases, specifically Rab4 and Rab11, which modulate the recycling pathway by separating sorting endosomes from transport end exocytotic vesicles [47]

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