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Clinical Trials in Nonvegetarians Theres been one clinical trial in nonvegetarians that suggested, on average, little benefit for B12 status from multivitamins

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Most studies are small-scale, lack robust methodology, or have not been replicated in larger populations

While theres no definite cutoff for when B12 starts to become unsafe, because people often ask, well somewhat arbitrarily say not to take more than 1,000 g per day over the long-term without guidance from a physician