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Cleft lip and palate are a component of more than 200 different congenital disorders, such as DiGeorge syndrome, Treacher-Collins syndrome, Nagers syndrome, and fetal alcohol syndrome

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Silent information regulator 1 (Sirt1), an anti-inflammatory and anti-oxidative protein (316), increases the production of NO by activating endothelial NOS (eNOS) in endothelial cells in response to shear stress (317)

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