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Chen found in human melanoma cells that silencing iPLA2 would enhance the sensitivity to p53-mediated ferroptosis without significant effects on cells that usually express iPLA2, suggesting that iPLA2 can inhibit p53-mediated ferroptosis, and p53-driven ferroptosis is independent of GPX4 [41]

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In that scenario, intravenous or intramuscular administration is usually used anyway

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8 Notably, adenylate kinase 2 (AK2) is significantly lactylated at lysine 28, influencing its function and promoting HCC cell proliferation and metastasis