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Furthermore, an altered bone metabolism that is caused by androgen excess is evident in PCOS

People with a history of gallstones may be at higher risk, but most people tolerate GLP-1 therapy without gallbladder complications

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Analogously, semaglutide protected diabetic cardiomyopathy mice against oxidative stress and apoptosis, and thereby improved cardiac dysfunction by activating Sirt1/AMPK pathway and restoring of Cx43 expression [108]