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[1] [2] Patients may legitimately require both medications simultaneouslyfor example, someone with obesity and rheumatoid arthritis, or a patient with asthma requiring corticosteroid therapy who is also managing weight-related health conditions

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Sanyal AJ, Friedman SL, McCullough AJ, Dimick-Santos L, American Association for the Study of Liver Diseases, United States Food and Drug Administration

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Metabolic adaptation may be occurring