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In mouse models, the team introduced combined therapy including PD-L1 blocker and cyst(e) inase (a bioengineered enzyme that degrades cystine and cysteine) and such treatment can enhance the efficacy of CTL-mediated anticancer effects, supporting the idea that inducing ferroptosis could be considered a productive way for treating cancer and overcoming immunotherapy resistance (Wang et al., 2019)

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52,53,54 In contrast, in conditions such as chronic obstructive pulmonary disease, 55 idiopathic pulmonary fibrosis, 56 hypertension, 57 type II diabetes, 58 neurodegenerative diseases, 59 cancer, 13 and systemic inflammatory response syndrome, 60 redox regulation indirectly influences disease progression through signal transduction pathways