Prior to reinstatement test sessions, the GLP-1R antagonist exendin-(9-39) (10 g/100nl) was infused directly into the VTA 10 minutes before administration of CNO (1.0 mg/kg, i.p.) to determine if pharmacological inhibition of VTA GLP-1Rs is sufficient to block the suppressive effects of chemogenetic activation of NTSVTA projections on cocaine seeking (Fig 3D)
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Our recent analysis shows that GLP-1s now account for more than 7% of all prescriptions in the US, reflecting both expanding indications and increasing demand ( 4 )
[PubMed] [Google Scholar] 16.Whitlock G, Lewington S, Sherliker P, Clarke R, Emberson J, Halsey J, et al