Using a human-specific albumin assay as a readout, we assessed the blood of mice over a 5-week period
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HER-2/neu encodes a receptor tyrosine kinase involved in mitogenic signaling via the MAPK and PI3K/AKT pathways and is implicated in the pathogenesis of multiple epithelial malignancies, including breast carcinoma
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Phase 1: Days 1-15 (1 mg/day) During the first 15 days, the dose is 4 units on an insulin syringe, which equals 1 mg per injection