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In some instances, upon administration of a controlled release auris formulation or composition described herein (e.g., a formulation comprising a therapeutic agent), drug concentrations relative to the binding constants of one or more otic receptors are relevant in determining a biologically meaningful PK profile or the minimum concentration of an active agent required for a therapeutic effect

"I knew my dream was to become a water polo player

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Several studies have shown that due to the interaction with high-density lipoproteins, vesicles that are composed of no more than one phospholipid, become leaky in plasma or serum

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