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NAFLD, Nonalcoholic fatty liver disease

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Given the intractable pediatric obesity epidemic and associated rise in type 2 diabetes in youth, made worse by the COVID-19 pandemic related shutdowns and disruptions in opportunities for exercise and play in youth, this new class of medications will certainly benefit children with morbid obesity and type 2 diabetes

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Interestingly, estrogens, especially 17-estradiol, have been recently shown to favor a resistance towards ferroptotic death through both genomic and non-genomic mechanisms [40]

Sitagliptin augments sympathetic enhancement of the renovascular effects of angiotensin II in genetic hypertension