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This is in concordance with preclinical data in rodents and nonhuman primates showing expression of GLP1Rs in brain regions involved in reward and addiction, for example, VTA, NAc, septal nucleus, hypothalamus and amygdala [35, 36, 37, 38, 39, 40]

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If berberine is included in the formulation (as the marketing language suggests, but the ingredient list does not confirm), it would represent an ingredient with more metabolic research, though primarily studied by oral administration rather than transdermal delivery

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This also protects skin elasticity, firmness, and plumpness, which in turn, prevents signs of premature ageing like fine lines