glp-1 heart failure Impact of receptor agonists on cardiovascular outcomes in with preserved ejection fraction (HFpEF): systematic review and meta-analysis | Clinical Research in Cardiology GLP-1 Agonist Therapy for Advanced

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Accessed 10/23/2019

It concluded: "There is a strong indication that GLP-1 receptor agonists may have a useful role in future treatment of Parkinson's disease." Of note, both trials had a washout period after the drug treatment ended and the benefit for motor symptoms persisted

However, when combined with insulin or sulfonylureas in research models of diabetes, hypoglycemia risk increases and dose adjustments of background therapies are typically recommended