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administration of AMG 133 to obese male cynomolgus monkeys are shown in Fig

Two months later further increase in patients BMI to 30.2 kg/m 2 was observed

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The authors identified that the dorsal raphe nucleus (DR) has serotonergic neurons that secrete serotonin to hypothalamic nuclei and that GLP-1R activation promotes the activity of DR serotonin neurons