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A previous clinical trial showed even greater average weight loss for Wegovy: about 15% on average over 68 weeks, compared with 2.4% for people who got a placebo

GIP pathway GIP receptor pathway research is commonly discussed alongside GLP-1 in dual agonist models

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The key difference lies in their energy targets

GLP1 drugs have antiinflammatory effects that may protect neurons

GLP-1 receptor agonists like semaglutide work by slowing stomach emptying and signaling fullness to the brain, achieving weight reductions of 1522% in clinical trials