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In elderly individuals, the capacity of DCs to phagocytose antigens and migrate is significantly impaired

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The studies summarized below reflect this evidence-base structure

Funding Statement This research was funded by an NIH-NIMHD Pilot Study Project Grant awarded to K.K

Cell Neurosci

Second, the current studies largely rely on cellular and animal models, whereas human colonic organoids may be more suitable since they are more physiologically relevant and better simulate the epithelial microenvironment