Semaglutide is a synthetic GLP-1 RA (receptor agonist)
it is part of the outcome
People taking diabetes medications should be cautious, as the combined effects of both MOTS-c supplementation and diabetes medications on blood sugar have not been studied extensively in humans
For full insight into our criteria for including and ranking GLP-1 providers, please review our full methodology
Its also recommended to be cautious in people on certain medications like levodopa (without carbidopa), as mentioned, or those with specific medical conditions, but these are matters of caution rather than strict contraindications
NICE guidelines recommend evidence-based weight management through dietary modification (600 kcal/day deficit), 150300 minutes weekly moderate-intensity physical activity, and behavioural change strategies