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Weight loss or hormonal shifts may contribute

Meanwhile, there were studies showing that weight regain can cause some metabolic indicators to revert back such as plasma lipids, blood pressure, fasting glucose, and insulin concentrations [18, 19]

The biological functions of carotenoids are closely related to their chemical structure

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Translational success will require (i) rigorous preclinical-to-clinical pipelines that include long-term toxicity and biodistribution studies, (ii) GMP- compliant manufacturing to ensure reproducibility and scalability, (iii) adaptive trial designs capable of evaluating patient-specific nanotherapies, and (iv) clearer regulatory alignment across FDA/EMA to classify and approve multifunctional nanoplatforms

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