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while the symptomatic acute COVID-19 condition could manifest into 3 clinical phases: (i) hypoxia and hypoxemia (Warburg effect), (ii) hyperferritinemia (cytokine storm), and (iii) thrombocytosis (coagulopathy)

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In the USP11 knockout mouse model of renal fibrosis, the degradation of EGFR was increased, which inhibited downstream signaling pathways and delayed the renal fibrosis and epithelial-mesenchymal transition[54]