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doi:10.1056/NEJMoa2301972 PubMed: This landmark study demonstrated 24.2% mean weight loss at 48 weeks with the 12mg dose in 338 adults with obesity, establishing retatrutide as the most effective obesity medication tested to date
Via this metabolic adaptation, cells can continually generate TCA metabolites, such as -KG and citrate, which are converted to cytosolic acetyl-CoA for lipid biosynthesis (Fig
Week six through twelve deliver sustained improvements in metabolism and recovery
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