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GLP-1R/GIPR GLP-1R (glucagon-like peptide-1 receptor) is a Class B G-protein-coupled receptor (GPCR) expressed in various tissues and organs, including pancreatic -cells, the stomach, small intestine, heart, kidneys, lungs, and brain

The enzyme activity is expressed as units/mg protein/min

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This overall suppression of signaling downstream of GLP1R is consistent with inhibitory GPCR signaling, which was confirmed by reduced cAMP levels

The cardiometabolic benefit is large, and the side effect profile is acceptable for that risk class

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