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c-KIT-mediated ERK signaling pathway can induces CREB phosphorylation to activate melanin synthesis on one hand, and on the other hand, the activation of ERK signaling has been demonstrated to phosphorylate MITF at the serine 73 residue, which leads to the ubiquitination and degradation of MITF, this is the feedback mechanism of the ERK pathway to regulate melanin production (3,35)

Neuroembryol Aging

H., Dinsdale, D., & Nemery, B

Fewer re-orders than the 60 and 90 count bottles most brands sell

31671026), the Research Project of Nanjing General Hospital (grant no

Both work synergistically for comprehensive anti-aging benefits