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It reflects a deeper immune imbalance involving the IL-17 and IL-23 inflammatory pathways, gut microbiome dysbiosis, genetic predisposition (HLA-B27 and related alleles), and environmental triggers including trauma, infection, and metabolic dysfunction

Gall midges (Hessian flies) as plant pathogens

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Additional diversity in TGF- signaling is achieved via activation of non-canonical, SMAD-independent pathways, including tumor necrosis factor (TNF) receptor-associated factor 4 (TRAF4), TRAF6, TGF--activated kinase 1 (TAK1