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Frontiers in pharmacology , 12 , 627533

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The STEP 4 withdrawal trial demonstrated that continued Semaglutide therapy was needed to maintain weight loss, as patients switched to placebo regained weight over 48 weeks (Rubino et al., JAMA 2021

instead, its proposed mechanism involves multiple downstream effects mediated by copper coordination chemistry and tripeptide-specific interactions with various proteins

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doi: 10.2147/DDDT.S82030